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Studies have revealed that knockdown of ULK inhibits autophagosome development. Mice with defects in ULK1 and ULK2 die in just 24 h soon after beginning [41]. When ULK1 is expressed in mammalian cells, ULK2 is just not needed for autophagy. However, when ULK1 expression is inhibited, ULK2 can compensate with the functionality of ULK1 in regulating